How Our Microbiome Influences Our Brain Development, Sense of Well-Being, Mood, Cognition, Stress Tolerance, Social Engagement, Aging Process & Conditions Such as ADHD, Autism & Alzheimer's.
The information on the gut microbiome and the effects of a "faulty" biome on our wellbeing are essential to gaining a more wholistic understanding of the multifaceted needs in regard to our health/wellbeing ...... but the approach of fiber and fermented food is not necessarily the approach for all .... and in fact could be disastrous for many, the whole concept of a more diverse diet leading to a more healthy microbiome makes no sense anthropologically .... it was availability that drove choice not diversity ... when I was first introduced to the insanity of hypersensitivity after a mold/drug stress injury back in the mid 1990s I entered the fiber fermented flax oil scene and was decimated by these substances ... only due to being an obsessive researcher did I come across a book which helped me to understand the power of food on our wellbeing, in this instance from a psychochemical perspective ... the book is "Nutrition and your mind" by George Watson MD. Most of the research I see today for metabolic health and its effect on our wellbeing was proposed back in 1974 by George Watson and prior by Weston Price (in a different approach). What I need to point out is that while removing processed carbs grains and oils etcetera is essential and probably beneficial for everyone .... fiber and fermentation may need to be withheld in favor of a high fat carnivore approach which is showing some quite remarkable results in terms of metabolic health .... it's not an either-or situation .... but it could be for many.
Thank you for adding this. Yes. There are definitely a lot of nuances here that I failed to elaborate on Many of the people I see have mold toxicity, mast cell activation and histamine intolerance and are unable to tolerate fermented foods. Others, including myself have MAOA and DAOA insufficiency and have never done well with them. And, yes, there are a range of issues beyond histamine from oxalates, lectins, high sulfur, FODMAPS and more. And too, I agree that some benefit from carnivore as part of a healing process. It was part of my own healing process. Thanks again.
I am going to try making L. reuteri yoghurt. Also the book "Super Gut" by Dr William Davis is on my reading list.
Maybe something that you will find interesting. It is getting quite the hype lately. Some say it helped them recover from Post SSRI syndromes and that it helps against SIBO and helps increase oxytocin.
Among my professional and avocational circles in the 1990s and '00s, there was much discussion of the mode of action of glyphosate, the key element of RoundUp herbicide.
Glyphosate inhibits a key enzyme (EPSPS) in the shikimate/shikimic pathway, which biosynthesizes lignin, folic acid, auxin, various aromatic amino acids, and more. EPSPS 1 is naturally found in plants, in fungi, and in many/most bacteria. Glyphosate moves in on a key binding site as a mimic, blocking the pathway.
As Monsanto was enthusiastically rolling out both RoundUp and RoundUp "ready" patented-lifeform seeds, and large farms were rushing to get in on the Big Ag gold rush, our question was--what will happen to gut ecology of people who eat foods with RoundUp/glyphosate residues? Wouldn't we expect to see mayhem among the bacteria, fungi, etc., in our onboard digestion tank? Would we expect to see more gut-brain axis issues among farmers and their families/communities where these chemicals were widely adopted, or found their way into groundwater? (We were already sponsoring or watching research on the interactive biological effects of herbicides and nitrates at very low doses...and unexpected hormonal, neurological, and behavioral effects were prominent.)
Since that time, use per acre of glyphosate has exploded, especially in row crops that form the basis of the industrial food system, like soybeans, canola, and wheat. Wine grapes also.
I'm guessing readers of the HP 'stack, and Dr. Snyder herself, will be aware of parents whose autistic children appeared to have strong positive behavioral effects after the parents switched them to an organic/biodynamic diet and put them on a gut-flora-rebuilding diet. Also observed: reduction of "gluten intolerance" symptems.
It took awhile to close the syllogism and see glyphosate as a potential unrecognized cause of gut dysbiosis, and that causing behavioral effects.
Sadly most of the citations I see on this topic are in silico studies, but some animal model studies are done. For example:
Thank you very much for adding this information. Though in my own thinking, I was including pesticides, heavy metals, mold toxins) under toxins, I definitely would have made sense to comment on a diet that is as organic as possible or at the very least eating organic produce that is especially higher (per EWG). I think tools to support the microbiome would be better served by being the topic of newsletter itself. Thank you again, for adding this.
The information on the gut microbiome and the effects of a "faulty" biome on our wellbeing are essential to gaining a more wholistic understanding of the multifaceted needs in regard to our health/wellbeing ...... but the approach of fiber and fermented food is not necessarily the approach for all .... and in fact could be disastrous for many, the whole concept of a more diverse diet leading to a more healthy microbiome makes no sense anthropologically .... it was availability that drove choice not diversity ... when I was first introduced to the insanity of hypersensitivity after a mold/drug stress injury back in the mid 1990s I entered the fiber fermented flax oil scene and was decimated by these substances ... only due to being an obsessive researcher did I come across a book which helped me to understand the power of food on our wellbeing, in this instance from a psychochemical perspective ... the book is "Nutrition and your mind" by George Watson MD. Most of the research I see today for metabolic health and its effect on our wellbeing was proposed back in 1974 by George Watson and prior by Weston Price (in a different approach). What I need to point out is that while removing processed carbs grains and oils etcetera is essential and probably beneficial for everyone .... fiber and fermentation may need to be withheld in favor of a high fat carnivore approach which is showing some quite remarkable results in terms of metabolic health .... it's not an either-or situation .... but it could be for many.
Thank you for adding this. Yes. There are definitely a lot of nuances here that I failed to elaborate on Many of the people I see have mold toxicity, mast cell activation and histamine intolerance and are unable to tolerate fermented foods. Others, including myself have MAOA and DAOA insufficiency and have never done well with them. And, yes, there are a range of issues beyond histamine from oxalates, lectins, high sulfur, FODMAPS and more. And too, I agree that some benefit from carnivore as part of a healing process. It was part of my own healing process. Thanks again.
I am going to try making L. reuteri yoghurt. Also the book "Super Gut" by Dr William Davis is on my reading list.
Maybe something that you will find interesting. It is getting quite the hype lately. Some say it helped them recover from Post SSRI syndromes and that it helps against SIBO and helps increase oxytocin.
Thank you, Albin. That book looks like a great tool. I'll check it out.
Among my professional and avocational circles in the 1990s and '00s, there was much discussion of the mode of action of glyphosate, the key element of RoundUp herbicide.
Glyphosate inhibits a key enzyme (EPSPS) in the shikimate/shikimic pathway, which biosynthesizes lignin, folic acid, auxin, various aromatic amino acids, and more. EPSPS 1 is naturally found in plants, in fungi, and in many/most bacteria. Glyphosate moves in on a key binding site as a mimic, blocking the pathway.
As Monsanto was enthusiastically rolling out both RoundUp and RoundUp "ready" patented-lifeform seeds, and large farms were rushing to get in on the Big Ag gold rush, our question was--what will happen to gut ecology of people who eat foods with RoundUp/glyphosate residues? Wouldn't we expect to see mayhem among the bacteria, fungi, etc., in our onboard digestion tank? Would we expect to see more gut-brain axis issues among farmers and their families/communities where these chemicals were widely adopted, or found their way into groundwater? (We were already sponsoring or watching research on the interactive biological effects of herbicides and nitrates at very low doses...and unexpected hormonal, neurological, and behavioral effects were prominent.)
Since that time, use per acre of glyphosate has exploded, especially in row crops that form the basis of the industrial food system, like soybeans, canola, and wheat. Wine grapes also.
I'm guessing readers of the HP 'stack, and Dr. Snyder herself, will be aware of parents whose autistic children appeared to have strong positive behavioral effects after the parents switched them to an organic/biodynamic diet and put them on a gut-flora-rebuilding diet. Also observed: reduction of "gluten intolerance" symptems.
It took awhile to close the syllogism and see glyphosate as a potential unrecognized cause of gut dysbiosis, and that causing behavioral effects.
Sadly most of the citations I see on this topic are in silico studies, but some animal model studies are done. For example:
https://pubmed.ncbi.nlm.nih.gov/39302074/
Here's a review:
https://pubmed.ncbi.nlm.nih.gov/38099711/
Thank you very much for adding this information. Though in my own thinking, I was including pesticides, heavy metals, mold toxins) under toxins, I definitely would have made sense to comment on a diet that is as organic as possible or at the very least eating organic produce that is especially higher (per EWG). I think tools to support the microbiome would be better served by being the topic of newsletter itself. Thank you again, for adding this.